Figure 1
Figure 1. RIP-Chip analysis of the hnRNP-A1–, hnRNP-E2–, hnRNP-K–, and La/SSB-associated mRNAs in CML-BC–derived Ph1+ K562 cells. Left column: Venn diagram of the RNAs associated with (A) hnRNP-A1, (B) hnRNP-E2, (C) hnRNP-K, and (D) La/SSB within the cytoplasm of Ph1+ K562 cells. The squares depict the genes available on the indicated Affymetrix chips. The gray ellipses represent the genes detected in lysate input. The white ellipses indicate the genes significantly enriched in the hnRNP-A1, hnRNP-E2, hnRNP-K, and La/SSB immunoprecipitates and not present in immunoprecipitates with a nonrelated antibody. Right column: tables show the hnRNP-A1–, hnRNP-E2–, hnRNP-K–, and La-associated mRNAs with a reported relevance in cancer. mRNAs are represented as fold increase versus negative control (anti-Flag or anti-HA) and fold increase versus total input RNA.

RIP-Chip analysis of the hnRNP-A1–, hnRNP-E2–, hnRNP-K–, and La/SSB-associated mRNAs in CML-BC–derived Ph1+ K562 cells. Left column: Venn diagram of the RNAs associated with (A) hnRNP-A1, (B) hnRNP-E2, (C) hnRNP-K, and (D) La/SSB within the cytoplasm of Ph1+ K562 cells. The squares depict the genes available on the indicated Affymetrix chips. The gray ellipses represent the genes detected in lysate input. The white ellipses indicate the genes significantly enriched in the hnRNP-A1, hnRNP-E2, hnRNP-K, and La/SSB immunoprecipitates and not present in immunoprecipitates with a nonrelated antibody. Right column: tables show the hnRNP-A1–, hnRNP-E2–, hnRNP-K–, and La-associated mRNAs with a reported relevance in cancer. mRNAs are represented as fold increase versus negative control (anti-Flag or anti-HA) and fold increase versus total input RNA.

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