Prognostic impact on TTT risk of cytogenetic abnormalities alone and in combination with CD49d. (A) Patients were split according to their karyotype in 3 groups and compared for TTT: normal karyotype (n = 75), presence of the unfavorable genomic aberrations 17p−, 11q−, and trisomy 12 (n = 46), presence of 13q− chromosomal aberration (n = 35). (B,C) Kaplan-Meier curves comparing TTT according to CD49d expression in the group with a normal karyotype (B) and in the group with presence of the unfavorable genomic aberrations (C). The numbers of patients (pts) included in each group are reported in parentheses; the reported P values refer to the log-rank test.