Figure 2
Figure 2. Activation via CD40 up-regulates IL-2Rβ and IL-15Rα expression by CLL cells. (A) RT-PCR analysis of IL-15Rα, IL-2Rβ, and γc mRNA expression on freshly purified (r) or on CD40-activated (a) CLL cells. A negative control (ctr) without RNA was also included. Amplification of the same cDNAs with β-actin–specific primers is also shown. (B) Immunofluorescence analysis of IL-2Rβ and IL-15Rα expression (heavy line) on freshly isolated or CD40-activated CLL cells from 2 representative cases. Light lines represent background fluorescence obtained by the use of irrelevant isotype-matched control Ig.

Activation via CD40 up-regulates IL-2Rβ and IL-15Rα expression by CLL cells. (A) RT-PCR analysis of IL-15Rα, IL-2Rβ, and γc mRNA expression on freshly purified (r) or on CD40-activated (a) CLL cells. A negative control (ctr) without RNA was also included. Amplification of the same cDNAs with β-actin–specific primers is also shown. (B) Immunofluorescence analysis of IL-2Rβ and IL-15Rα expression (heavy line) on freshly isolated or CD40-activated CLL cells from 2 representative cases. Light lines represent background fluorescence obtained by the use of irrelevant isotype-matched control Ig.

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