Representative flow cytometric analysis of bone marrow and spleen cells. (A) Ts65Dn mice harbor increased CD41⁺ cells in the bone marrow and spleen (left panels). CD41⁺ megakaryocytes from Ts65Dn animals show an increase in the lower ploidy classes in both organs (right panels). (B) Ts65Dn mice display increased c-kit expression in the bone marrow. (C) The ratio of CD19⁺ to CD3⁺ lymphocytes is diminished in Ts65Dn mice. Numbers on plots and on histogram peaks represent the percentage of the total population of cells in the rectangle.