Association of clinical phenomena with dysregulated B-cell subpopulations. The box plots indicate the most significant dysregulations of B-cell subpopulations in patients with splenomegaly (A), lymphadenopathy (B), and granulomatous disease (C). Boxes indicate median, 25th and 75th percentiles. The bars indicate minimum and maximum values, excluding outliers and extreme values. PBL indicates peripheral blood lymphocytes.