Coincidence of granulomatous disease and autoimmune cytopenia with splenomegaly in patients with CVID. The diagram indicates the coincidence of splenomegaly, granulomatous disease, and autoimmune cytopenia in the European cohort of CVID patients. In 3 patients, granulomatous disease and autoimmune cytopenia were detectable in the absence of splenomegaly (sickle shape).