A_2AR stimulation in vivo prevents death by autoimmunity and promotes T-cell tolerance. (A) Survival curve of C3HA mice given 6.5⁺ T cells and 4 days of vehicle (□) or CGS (♦) (n = 17 mice, each condition). (B-D) In vitro proliferation (B), IFN-γ production (C), and IL-2 (D) of T cells harvested from vehicle- or CGS-treated C3HA mice ( and , respectively). Data are representative of 2 independent experiments, ≥3 mice per group. (E,F) Number of IFN-γ (E) and IL-17 (F) lung-infiltrating 6.5⁺ T cells from C3HA mice given a lethal dose of autoreactive T cells. Data are a combination of 2 independent experiments, 3 mice per group (*P < .05).