Telomere length analysis in family B. (A) Healthy subjects are indicated by ○. The best-fit-line through this normal range is shown as a black line that corresponds to the equation Y = 17.821 − 0.0407X. Deviation from the best-fit-line has been highlighted as a dark gray box for 68%, a lighter gray box for 90%, and the palest gray box for 95%. The healthy brother is highlighted as a ◇, while the heterozygous R901W parents are ⧫ and the homozygous R901W index case is a ◆. (B) The Δtel values from healthy subjects from panel A (n = 112) are represented on a linear graph and compared with the R901W family (family B). (C) A random selection of subjects (n = 26) was also analyzed using the T/S ratio method⁴⁵  and plotted to show the relationship to their TRF measurements in panel A. A linear trend line was added for correlation analysis (R² = 0.6917). (D) Family B was also analyzed using the T/S ratio method and compared with the healthy subjects from panel C.