Figure 1
Figure 1. Aberrant expression of Cdx2 up-regulates Hox gene expression in murine bone marrow progenitors. (A) Fold expression levels of Hox genes in murine BM progenitors induced by ectopic expression of Cdx2 or the ΔN-Cdx2 mutant (ΔN) referred to the expression level in BM progenitors transduced with the EGFP control vector 48 hours after the end of transduction. (B) Fold expression levels of Hox genes in primary colonies expressing Cdx2, ΔN-Cdx2, or the empty control vector (EGFP). The fold expression was calculated by the rρCT method based on the expression level of the Hox genes in cells transduced with the EGFP control. *Expression of Hoxb6 and Hoxb8 were not detectable in EGFP control cells. Error bars indicate the standard deviations (SD).

Aberrant expression of Cdx2 up-regulates Hox gene expression in murine bone marrow progenitors. (A) Fold expression levels of Hox genes in murine BM progenitors induced by ectopic expression of Cdx2 or the ΔN-Cdx2 mutant (ΔN) referred to the expression level in BM progenitors transduced with the EGFP control vector 48 hours after the end of transduction. (B) Fold expression levels of Hox genes in primary colonies expressing Cdx2, ΔN-Cdx2, or the empty control vector (EGFP). The fold expression was calculated by the rρCT method based on the expression level of the Hox genes in cells transduced with the EGFP control. *Expression of Hoxb6 and Hoxb8 were not detectable in EGFP control cells. Error bars indicate the standard deviations (SD).

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