GATA2 patients have unique transcript profiles compared with healthy normals and diseased controls. Normalized transcript counts from nCounter analysis used for (A) 2-dimensional principal component analysis of patients with GATA2 i5C>T (patients 4.II.1, 11.II.1, 25.I.1), missense mutation (GATA2 Mis; patients 15.I.1, 19.II.1, 30.II.1), and reduced allelic expression without identified GATA2 mutation (GATA2 Unk; patients 7.I.1, 29.I.1) compared with healthy controls and diseased controls with similar infection types but wild-type GATA2. Fungal, disseminated coccidioidomycosis or histoplasmosis; Mycobacteria, disseminated mycobacteria; Cryptosporidiosis, disseminated cryptosporidium. (B) Hierarchical clustering of transcripts differentially regulated (P < .05) between healthy normals and GATA2 mutated patients irrespective of genotype. Samples and color labels correspond to mutations as in A.