Relative expression of HIF target genes induced by hypoxia and AML1/RUNX1 and NF-E2 genes. (A) Expression of TFRC, SLC2A1, and HK1 genes and (B) AML1/RUNX1 and NF-E2 genes was evaluated by quantitative polymerase chain reaction in granulocytes isolated from homozygous patient for VHL^P138L mutation (grey columns), and normal controls (n = 8, white columns). Data are normalized to HPRT and GAPDH reference genes. T bars = SEM. *P < .01.