Figure 1.
Figure 1. Sub-clones present in diagnostic sample before intratibial injection into NOD/SCID/IL2Rgamma(null) mice, assayed by 3 colour FISH for the ETV6-RUNX1 gene fusion, ETV6 deletion, RUNX1 gain and CDKN2A deletion. All four leukaemic subclones were present in the mice after leukaemic engraftment at 10 -12 weeks, but with the CDKN2A deleted sub-clones predominant.

Sub-clones present in diagnostic sample before intratibial injection into NOD/SCID/IL2Rgamma(null) mice, assayed by 3 colour FISH for the ETV6-RUNX1 gene fusion, ETV6 deletion, RUNX1 gain and CDKN2A deletion. All four leukaemic subclones were present in the mice after leukaemic engraftment at 10 -12 weeks, but with the CDKN2A deleted sub-clones predominant.

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