Sepsis-induced increases in plasma cytokines are attenuated in P2Y12 KO mice following CLP. Plasma levels of TNF-a, IL-10, IL-6 and MIP-1b in wild type (black) and KO mice (white). Values are expressed as pg/ml, mean ± SEM (*p < 0.05; **p < 0.01; KO CLP model versus WT CLP, n=5).