Contribution of the intrinsic and extrinsic pathways to SC formation.

(A) Typical clot growth images in plasmas of patients, either untreated, or supplemented with VIIai (50 nM), or with CTI (200 μg/ml), or both. Note formation of numerous fibrin clots independent of the TF-iduced thrombus growth (on the bottom of each image). (B) Spontaneous clotting times for ten different patients as determined in the four experimental designs shown in panel A. In most patients, the role of contact pathway is the predominant one.