Improved overall survival (OS) based on integrated serum miRNA risk score vs clinical risk score alone. (A) Based on the integrated S-miR-16/25 risk score for OS where the score reflects the sum of the following risk factors: ISS stage III, del17, male gender, low miR-16, or low miR-25. Only two patients had an integrated risk score of 5 they were incorporated with score 4. (B) Clinical score groups reflects the sum of the following risk factors: ISS stage III, del17, and male gender.