MDS Dysregulated Pathways and Predicted Therapies. MDS patient-specific avatars illustrating predicted dysregulated pathways were created using next generation sequencing and a novel simulation software method. Depicted here is one pathway map from a patient with U2AF1 gain-of-function mutation, TP53 loss-of-function mutation, and various chromosome copy number mutations affecting DUSP1, PTPN1, MAPK9, AURKA, BCL2, and other pathways. The downstream pathways effects are mapped and the totality of mutations is predicted to cause increased MDS cell proliferation and viability. FDA-approved drugs predicted to impact dysregulated pathways (in this case, simvastatin (orange) and metformin (red)) are also shown in the map at critical impact points.