Changes in fatty acid metabolism allow for selective elimination of pathogenic T cells. T cells were recovered from allogeneic recipients (GVHD), recipients immunized with antigen-bearing dendritic cells (Imm), or naïve donors and assessed for FA transport (A) or levels of the transcriptional co-activator PGC-1α (B). C, Allogeneic recipients were treated for two weeks with the FA oxidation inhibitor etomoxir (Eto), or PBS as a control, and clinical scores assessed for individual mice on days 28, 35, 42, and 49 post-transplant. The average clinical score is represented by a solid line. (*** p<0.0001)