(a) Fibrin deposition and (b) leukocyte and platelet adhesion upon whole blood perfusion of endothelialized microchannels, pre-activated with 1 vs. 10ng/mL of TNF for 6 hours. (c) Role of endothelial TM in TNF-dependent microvessel thrombosis. TM blockade exacerbates fibrin deposition whereas ICAM-targeted TM fusion protein effectively eliminates coagulation.