The role of the plasma antithrombin and fibrinogen levels in the attenuation of the thrombin inactivation capacity in patients on VKA. (A) Antithrombin levels in healthy subjects and patients; (B) Fibrinogen levels in healthy subjects and patients. (C-D) The correlation of the thrombin decay capacity with antithrombin (C) and fibrinogen levels (D). (E) The measured thrombin decay capacity in healthy subjects and patients. (F) The simulated thrombin decay capacity in heathy subjects and patients at physiological fibrinogen levels. *p<0.05, **p<0.01, ***p<0.001 compared to healthy subjects.