A potential clinical progression map. On the X and Y axes of each graph are the relative level of phosphorylated Stat-3 and Stat5 present in each cell. The cells become denser; these are displayed as contour maps. The lower panel set by the basal phosphorylation states of the blood cells without any stimulation. The red circle in the bottom left-hand set of three panels represents where unstimulated cells from a normal individual would lie. As can be seen already in all of these patients there is at least a basal increase in the phosphorylation state of Stat3. As noted in the primary text, G-CSF stimulation results in the appearance of the subpopulation of cells, most predominant in patient 14 and patient 11, that are increasingly positive for either Stat3 or Stat5. The open circles in patient 26 and patient 23 demarcate a subpopulation of cells that might be the initial evolution of a signaling clonotype that is more obviously evidenced in patient 14 and patient 11.