Figure 1.
![Figure 1. Supra large VWF multimers in 3 siblings (thrombotic thrombocytopenic purpura [TTP]) with hereditary ADAMTS13 deficiency compared to normal plasma (NP). Activation of ADAMTS13 in normal plasma (NP +a) results in complete proteolytic cleavage of VWF multimers, whereas VWF in the TTP patient (TTP +a) remains unchanged due to the lack of ADAMTS13.](https://ash.silverchair-cdn.com/ash/content_public/journal/hematology/2006/1/10.1182_asheducation-2006.1.86/5/schneppenheim_fig1.jpeg?Expires=1722681509&Signature=rqpurcz2cFBLikmhk3o6hr~y~ofHTpfu8fBqi7SB8aULYQQmKsr8Hlvbs8K33sIGTZyJHT2uocFsWqQCVY~LeY~GjXUrlM~YWE9VPqMLRb1J~69-2Mic2HOG~j4ljR7gYJONWckVV3CNMSOISETKd3ec0wNX3LkHDx8P2sj9ZlW2EYLt3jfb1UYR-N-~khljx49L0WdgOyr06IanQjjRfRK7jnCyEW4ItZa4PaMu7FYWmowk5M4pSAoQhCX0mQ72vscrm~GXF54FUFxMCbCsAWszcqEiAUS7Fagkn-e6wOSTvJiC0SPmk0ar2KusMQJwSWkbuAcGopACqgNo8nj78g__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Supra large VWF multimers in 3 siblings (thrombotic thrombocytopenic purpura [TTP]) with hereditary ADAMTS13 deficiency compared to normal plasma (NP). Activation of ADAMTS13 in normal plasma (NP +a) results in complete proteolytic cleavage of VWF multimers, whereas VWF in the TTP patient (TTP +a) remains unchanged due to the lack of ADAMTS13.
