Effect of VKORC1 haplotype on warfarin dose stratified by VKORC1 haplotype and CYP2C9 status: either wild type (WT) or CYP2C9*2 and/or CYP2C9*3 mutants (MUT).

Primary cohort: UW (N = 185); Replication cohort: Wash U (N = 368).

Reprinted with permission from Rieder MJ, Reiner AP, Gage BF, et al. Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose. N Engl J Med. 2005;352:2285–2293.