Cartoon of FLT3 structure.

Shown in schematic fashion are the 5 immunoglobulin-like folds that make up the ligand-binding extracellular domain, single transmembrane domain, and cytoplasmic domain made up of a kinase domain interrupted by a kinase insert. The juxtamembrane domain where internal tandem duplications (ITDs) occur, and aspartic acid 835 where most kinase domain mutations occur are indicated by arrows.