Prothrombin conversion in APS patients and controls. Average prothrombin conversion curves are shown for healthy controls (dashed line) and APS patients (continuous line) at 1 (A) and 5 (B) pM TF. Prothrombin conversion parameters for the total amount of prothrombin converted (PC_tot; C,E) and maximum rate of prothrombin conversion (PCmax; D,F) were quantified for 1 and 5 pM TG curves, respectively. ***P < .001, **P < .01 according to a 2-sided Mann-Whitney U test.