PIM inhibition abrogates IL-7–mediated T-ALL cell growth, proliferation, cell cycle progression, and CD71 expression but does not impact cell viability or Bcl-2 expression. IL-7-deprived TAIL7 or PDX T-ALL cells were cultured in medium, IL-7, or IL-7 plus the pan-PIM inhibitor AZD1208 (1 µM) and analyzed by flow cytometry for viability (A), intracellular Bcl-2 levels (B), cell size (C), CD71 surface expression (E), cell cycle (D), and proliferation (F). Results are representative of 2 independent experiments or 2 PDX. Results in graphics represent average of triplicates ± SEM. *P < .05; **P < .01; ***P < .001.