Genetic deletion of CD73 in SCD mice decreases multiorgan damage including lung, spleen, and liver. (A) H&E staining of lungs, spleens, and livers of WT BMT, SCD BMT, and SCD/CD73^−/− BMT mice (magnification ×200). (B-D) Semiquantitative analysis of H&E-stained sections show decreased lung congestion, spleen necrosis, and liver necrosis in SCD/CD73^−/− BMT mice compared with SCD BMT mice. (E-G) MPO activity in multiple organs including lung, spleen, and liver in SCD/CD73^−/− BMT mice compared with SCD BMT mice. Data are expressed as mean ± SEM. n = 5 for each group; *P < .05 vs WT, **P < .05 vs SCD, Student t test.