Validation of the 6-month EUMDS classifier. Kaplan-Meier plots of OS in the external validation cohort (n = 335) according to platelet drop >25% at the 6-month landmark (blue, relative platelet drop ≤25%; red, relative platelet drop >25%) (A) and the 6-month EUMDS classifier (B). (C) CIP according to the 6-month EUMDS classifier. (B-C) Blue, no criteria; red, either criteria; green: both criteria.