TL in BCR-ABL⁻vs BCR-ABL⁺cells of CP CML patients at first diagnosis. (A) TL (in a.u.) in CD34⁺CD38⁻ BCR-ABL⁺ LSC is significantly shortened compared with BCR-ABL⁻ HSC (P = .040). (B) Difference in TL between BCR-ABL⁺ LSC and BCR-ABL⁻ HSC (ΔTL^LSC-HSC, in a.u.) as a function of clone size (ie, the percentage of Ph⁺ cells) in the BM CD34⁺CD38⁻ population of CP CML patients at diagnosis (r² = 0.367, P = .016).