Activation of ATM associates with CD40L/IL-4 responses. (A) Western blots showing the effects of CD40L/IL-4 culture and XR (5 Gy) on levels of ph-ATM, ph-p53, and ph-CHK2. GAPDH is the loading control. Patient ID is given above (labeled 37 to 47) the autorads. Those samples that received XR are indicated. (B) Correlation between levels of total and ph-ATM after CD40L/IL-4 stimulation and ATP response (R² = 0.61, P = .0048). (C) Levels of total ATM after CD40L/IL-4 stimulation correlated with fold-increase in viability due to CD40L/IL-4 (R² = 0.4, P = .03). (D) Levels of ph-ATM after CD40L/IL-4 stimulation correlated with fold-increase in viability due to CD40L/IL-4 (R² = 0.68, P = .002). (E) Fold increase in ph-ATM after CD40L/IL-4 stimulation correlated with fold-increase in viability due to CD40L/IL-4 (R² = 0.4, P = .035).