Figure 6.
![Figure 6. Influence of SNV on VWF expression and half-life in a murine model. (A) Alignment of VWF amino acids p.789-795 across species. (B) Alignment of VWF nucleotides c.2365-2385 between human and mouse. (C) Expression of murine c.[2365G>A;2367T>C], c.2385C>T and c.[2365G>A;2367T>C;2385C>T] in vivo. **P < .0001. (D) Expression of wild-type and c.[2365G>A;2367T>C;2385C>T] murine VWF 4 weeks posthydrodynamic injection. (E) Half-life of plasma-derived murine VWF in VWF knockout mice. (F) Stabilization of endogenous FVIII:C in VWF knockout mice.](https://ash.silverchair-cdn.com/ash/content_public/journal/bloodadvances/2/13/10.1182_bloodadvances.2017011643/3/advances011643f6.jpeg?Expires=1722362229&Signature=v2DYWQRoHRm1fj84NXjgzeAYYbx9Z1AuCW-OJeaw4zB1oE-yV~v-CCPRNChRPYYH--s~9KeQ71gdvqwVdNRYlvuarPIGXLKWsnZMu05VAvydY6MMqBiGeUP9BZV6zu8rrpmJSxxzhnJ7tFiDRPTcVGoQOgzNxAd1BFtxi~kiJR4eF3jZFA4qNeNeIaTZ3NLePqySg3HlKpG-ZBK9pUKVNs3YYU2tj2qclBdoXwkwNPTdLpOc0iYF-ZPVPh6bwoN1V4QkHWP64ASGos4MkPU7GAJIOGYntAH2kkeUhAINyzKUHvNVm3dbADi67XM9jElY4nrW0NAvQK7lIr9dfcqpUA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Influence of SNV on VWF expression and half-life in a murine model. (A) Alignment of VWF amino acids p.789-795 across species. (B) Alignment of VWF nucleotides c.2365-2385 between human and mouse. (C) Expression of murine c.[2365G>A;2367T>C], c.2385C>T and c.[2365G>A;2367T>C;2385C>T] in vivo. **P < .0001. (D) Expression of wild-type and c.[2365G>A;2367T>C;2385C>T] murine VWF 4 weeks posthydrodynamic injection. (E) Half-life of plasma-derived murine VWF in VWF knockout mice. (F) Stabilization of endogenous FVIII:C in VWF knockout mice.
