Figure 4.
![Figure 4. mRNA half-life of recombinant VWF. WT VWF (half-life [t1/2] = 2:36 hours) compared against (A) SNV c.2365A>G (t1/2 = 2:51 hours; 8.1% increase); (B) SNV c.2385T>C (t1/2 = 2:49 hours; 7.7% increase). (C) Both SNVs in cis (t1/2 = 2:54 hours; 10.0% increase). (D) Comparison of fold change in mRNA half-life between genotypes. Genotypes compared using an unpaired Student t test (*P < .05; **P < .01). Bars indicate standard error of the mean.](https://ash.silverchair-cdn.com/ash/content_public/journal/bloodadvances/2/13/10.1182_bloodadvances.2017011643/3/advances011643f4.jpeg?Expires=1722362760&Signature=2NNgrQXg4q243Mk9Cl-PC0Una~149Snhp5LTqy2-IZ4HZdC5p9al8SjA9bxqShzPVaeRQvk7Y9yI9sXXTWyNP-RwRXQeHO~l16f7xG3~YoN6b3Rk9GhaoScMMEB1oomNXvG06T8T0Evm28lHNOoWcYT1P5cnFODZ3Hb8DJnzYfZMaBtzdrDPMuBXmzVCdnXAGiB3XLSSOgQ-orQ4Avm8mnPE93-CoZIYJBS63va~ceTMiKIaOCVkyW5VdSQMwA9OZiX1knRa85ejmb4d2Mt1-~XQ5CYgmI2OuJhGZQLbn0fHApdZfu0s6d8KwCulgEwsvbpYbXyd4usSeSv2miCSWQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
mRNA half-life of recombinant VWF. WT VWF (half-life [t1/2] = 2:36 hours) compared against (A) SNV c.2365A>G (t1/2 = 2:51 hours; 8.1% increase); (B) SNV c.2385T>C (t1/2 = 2:49 hours; 7.7% increase). (C) Both SNVs in cis (t1/2 = 2:54 hours; 10.0% increase). (D) Comparison of fold change in mRNA half-life between genotypes. Genotypes compared using an unpaired Student t test (*P < .05; **P < .01). Bars indicate standard error of the mean.
