Association between SNV genotype and median VWF:Ag and FVIII:C levels in HCs. (A) SNV c.2365A>G and VWF:Ag levels. (B) SNV c.2385T>C and VWF:Ag levels. (C) Both SNVs in cis and VWF:Ag levels. (D) SNV c.2365A>G and FVIII:C levels. (E) SNV c.2385T>C and FVIII:C levels. (F) Both SNVs in cis and FVIII:C levels. Genotypes compared using a Mann-Whitney U test (*P < .05; ****P < .0001). Bars indicate 95% CI. NR, nonreference allele; ns, not significant; R, reference allele.