Evolving changes in hemoglobin, m-protein, free light chain ratio, and differences in free light chain identified through GBTM 1 year after diagnosis of SMM. (A) Changes in Hb are in g/dL. Changes in m-protein (B), free light chain ratio (C), and differences in free light chain ratio (D) are % from baseline. The trajectories of high risk evolving GBTM groups are indicated.