Figure 1.
Figure 1. VWD type 2B phenotypes in WT mice overexpressing VWF/p.V1316M. (A) Platelet counts in WT mice expressing only VWF/WT (n = 26, red circles; mean platelet count set to 100%) and mice expressing VWF/p.V1316M (n = 25, blue circles) 4 days after hydrodynamic gene transfer. The right axis shows absolute platelet count. (B) Platelet size; the left axis represents relative values, and the right axis represents FSC values. (C) Representative images of platelet aggregates in blood smears from WT-VWF/p.V1316M mice, stained with eosin and methylene blue. Images were acquired with a Nikon TE300 microscope and 100×/1.4 NA oil objective (Nikon Instruments, Melville, NY) equipped with a QImaging Retiga EXi CCD camera (QImaging, Surrey, Canada) using SlideBook software version 5.0, Intelligent Imaging Innovation. Total magnification ×1000.

VWD type 2B phenotypes in WT mice overexpressing VWF/p.V1316M. (A) Platelet counts in WT mice expressing only VWF/WT (n = 26, red circles; mean platelet count set to 100%) and mice expressing VWF/p.V1316M (n = 25, blue circles) 4 days after hydrodynamic gene transfer. The right axis shows absolute platelet count. (B) Platelet size; the left axis represents relative values, and the right axis represents FSC values. (C) Representative images of platelet aggregates in blood smears from WT-VWF/p.V1316M mice, stained with eosin and methylene blue. Images were acquired with a Nikon TE300 microscope and 100×/1.4 NA oil objective (Nikon Instruments, Melville, NY) equipped with a QImaging Retiga EXi CCD camera (QImaging, Surrey, Canada) using SlideBook software version 5.0, Intelligent Imaging Innovation. Total magnification ×1000.

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