The somatic mutations detected in HLA⁻granulocytes. (A) A summary of targeted sequencing of the 15 cases. Somatic mutations (red), nonsynonymous mutations of unknown significance (green), and synonymous mutations (pink) are shown. (B) The somatic mutations in HLA⁻ granulocytes and HLA⁺ granulocytes (left, DNMT3A, ZRSR2 and TET2 mutations in case 1; top right, a DNMT3A mutation in case 2; bottom right, a CBL mutation in case 4). HLA⁺ granulocytes of cases 2 and 3 were not assessable due to the paucity of the cell populations. Two different TET2 frameshift mutations were detected in case 1’s HLA⁻ granulocytes and HLA⁺ granulocytes, respectively. (C) The somatic mutations detected by whole-exome sequencing (WES) in 5 cases. del., deletion.