ODSH effect on blood counts in RIT in hPF4⁺/Cxcl4^−/−mice. (A) Nadir platelet counts of irradiated (6.5 Gy) hPF4⁺/Cxcl4^−/− animals as percentage of baseline platelet count, which occurred at day 10 for ODSH-treated animals vs control Cxcl4^−/− at day 12. P < .05. N = 20 animals per treatment arm. (B) Same as panel A but showing recovery of platelet count to baseline (dashed line demonstrates 100% baseline) after irradiation showing statistically different platelet counts starting at day 12 postirradiation (**P < .01 by Student t test after Bonferroni correction). N = 5 animals per arm. (C) Same as panel A, but showing survival of animals after irradiation, demonstrating improved survival in ODSH-treated animal (P < .04 by the Gehan-Breslow-Wilcoxon test). N = 20 animals per arm. (D) Same as panel A, but showing weight loss as percentage starting body weight for animals treated with ODSH or vehicle control. Dashed line is baseline body weight. N = 20 animals per arm. P < .001 for difference in curves.