Distribution of CDA activity in patients with no severe toxicities, in patients with severe toxicities, and in patients with lethal toxicities. One-way ANOVA with Newman-Keuls multiple comparison testing showed that CDA values in patients with no severe toxicities were significantly different than those in patients with severe/lethal toxicities. No difference was found in CDA values between patients with severe toxicities and those with lethal toxicities. G, grade.