Schematic diagram: the HIF-1α/KDM3A/MALAT1 positive feedback loop has an oncogenic role under hypoxia in MM. HIF-1α upregulates KDM3A as well as glycolytic genes under hypoxia. This histone modulator maintenance of the expression of MALAT1 long noncoding RNA leads to accumulation of HIF-1α. This HIF-1α-KDM3A-MALAT1 positive feedback loop contributes to survival of MM cells under hypoxia via enhancing genes controlling the glycolysis pathway.