Comparison of C/EBPα binding after induction and after RUNX1-ETO or RUNX1-EVI1 knockdown. (A,C) ChIP-seq of C/EBPα after E2 induction in (A) C/EBPα-ER Kasumi-1 or (C) C/EBPα-ER SKH1 cells. Peaks are ranked in order of decreasing relative DNA sequence tag count for peaks in control cells. Aligned to these coordinates are the indicated motifs, ChIP-seq sequences for either RUNX1-ETO (in Kasumi-1) or RUNX1-EVI1 (in SKH1), and C/EBPα ChIP-seq after either control siRNA or CBF fusion knockdown in the respective cell lines. Overlap of C/EBPα ChIP-seq peaks in (B) C/EBPα-ER Kasumi-1 or (D) C/EBPα-ER SKH1 cells after E2 and ethanol treatment.