Response to knockdown of RUNX1-EVI-1 and RUNX1-ETO converges on a C/EBPα-driven differentiation program. (A) Structure of RUNX1-EVI1 and RUNX1-ETO. NHR, nervy homology region; RD, proline-rich repressive domain; RHD, Runt homology domain; SET, Su(var)3-9 and enhancer of zeste and trithorax; ZF, zinc finger domain. (B) Hierarchical clustering of GO terms for upregulated or downregulated genes (1.5-fold difference) after either RUNX1-EVI1 or RUNX1-ETO knockdown compared with control siRNA. Expression after treatment was measured after 10 days in SKH-1 cells or 4 days in Kasumi-1 cells. The blue box identifies GO terms commonly upregulated after knockdown of both RUNX1-ETO and RUNX1-EVI1. (C) Selected examples of upregulated or downregulated genes.