The MRI26194 and MRI53426 Sptb-mutant lines are resistant to P chabaudi adami DS and P yoelii NL infection. Mice were infected with either P chabaudi (1 × 10⁴ parasites; 7-12 mice per group) (A) or P yoelii (1 × 10⁵ parasites; 8-15 mice per group) (B). Cohorts were analyzed for survival, percentage infected blood cells (parasitemia), percentage of reticulocytes, and RBC count (as a percentage of RBC count in uninfected mice). Mean and standard error of the mean are indicated. The log-rank (Mantel-Cox) test was used to calculate P values for survival; Mann-Whitney U test was used otherwise. *P < .05, **P < .01, ***P < .001 between Sptb^MRI26194/+ and WT. #P < .05, ##P < .01, ###P < .001 between Sptb^MRI53426/+ and WT.