sGPVI is detectable in patients with thermal injury and raised in patients who develop sepsis. (A) sGPVI levels of patients with thermal injury (n = 99) during the full time course, from day 1 to month 12 (M12) compared with HCs (n = 15). Mann-Whitney U test was performed to compare each patient time to HC (median shown). (B) Platelet counts of patients with thermal injury split into nonseptic and septic groups, measured using the Sysmex XN-1000-Hematology Analyzer, during the full-time course (median shown). (C) Peak sGPVI levels in patients with thermal injury of septic and nonseptic patients and HCs. Patients with thermal injury who developed sepsis are defined as meeting at least 3 of the American Burn Association sepsis criteria and a positive culture. Mann-Whitney U test was performed to compare sGPVI levels of septic patients compared with nonseptic burn patients and HCs (median shown). (D) Comparisons of sGPVI levels after platelet count normalization in patients with thermal injury who developed sepsis compared with nonseptic patients during the time course. Mann-Whitney U test was performed to compare sGPVI levels of septic patients and nonseptic burns patients (median shown). (E) D-dimer levels of patients with thermal injury higher than 15% TBSA (n = 61) over time compared with HCs (n = 12). (F) Longitudinal analysis of sGPVI as a moderate predictive marker of sepsis progression in patients with thermal injury. A linear mixed-effects model examining the relationship between sGPVI and time according to sepsis status. Line represents mean predicted effects, and shaded area represents 95% confidence interval.