sGPVI is detectable in patients admitted to ICU and associated with patient mortality. (A) sGPVI levels were measured in plasma from patients admitted to ICU in samples obtained at day 1 (T1) and 48 hours after admission (n = 83) compared with HCs (n = 24). Blue dots represent sGPVI levels in patients that increased after 48 hours. Median shown. (B) sGPVI levels measured in ICU patients who developed sepsis at T1, 48 hours after admission, Tx (day of sepsis diagnosis), and Tx+7. (C) D-dimer levels of ICU patients at day 1 (T1) and 48 hours after admission to ICU. Levels below 0.5 mg/L FEU were considered normal, levels from 0.5 to 4.0 mg/L FEU moderately increased, and levels more than 5.0 mg/L FEU strongly increased.41 (D) Association of sGPVI levels and patient mortality. Kaplan-Meier curve based on sGPVI levels at T1. Solid line represents low sGPVI levels below the median (sGPVI low; ≤22.3 ng/mL), and the dotted line represents high sGPVI levels above the median (sGPVI high; >22.3 ng/mL).
