Early and late relapses show distinct clonal dynamics. The “dynamic mutation rate” (number of dynamic mutations per Mb per day) was calculated from WES data by considering mutations showing a significant VAF shift only (see “Methods”). Each value represents the clonal dynamics of a tumor between 2 events (either PT vs R1 or R[n] vs R[n + 1]). Patients are divided into 6 panels depending on their survival or refractory status and on the delay before relapse events. R1 stands for the analysis of PT vs R1, R2 for R1 vs R2, R3 for R2 vs R3, and R4 for R3 vs R4. The dynamic mutation rate was significantly reduced in late relapses compared with early events (P = .0094, Mann-Whitney U test) and in nonrefractory compared with refractory events (P = .0473, Mann-Whitney U test).