Genes upregulated by PAM3 vs M-CSF and associated regulatory networks. Purified monocytes from 5 donors were stimulated for 4 hours as described in Figure 1. Their changes in gene expression were monitored by microarray. Upregulated genes were identified by comparison with untreated cells from the same donor using a stringency cutoff of P < .0001. All genes with regulatory interactions that could be mapped by IPA were then linked by network analysis. Critical networks are connected by black lines.