Effect of repeat dosing of GSK3277329 (5 and 15 mg/kg subcutaneous injection once a day) on circulating neutrophil counts and the correlation with G-CSF levels in M fascicularis. (A) Neutrophil counts before, 6 hours after, and 24 hours after the first dose of GSK3277329 and the seventh dose. Significant difference compared with predose group (t = 0) determined by 2-way ANOVA followed by Sidak’s post hoc test (*P < .05, **P < .01). (B) Correlation plot between circulating G-CSF levels and neutrophil counts measured 6 hours after GSK3277329 administration, grouping all animals from both dosing groups and samples collected after the first and seventh dose (3 animals per dose group).