Model-estimated relationships between PT ratio and event risks in FXa inhibitors estimated by a MBMA. (A) Ischemic stroke/SE. (B) Major bleeding. The solid curves and shaded areas represent the median estimates and 95% CIs, respectively. The symbols indicate observations in clinical trials vs the population means of the time-average of the PT ratio. The horizontal lines on the symbols represent the range between the trough and peak of the PT ratio as the population mean, and the vertical lines represent the 95% CI of the observations.