Increased output of bone marrow-derived naive B cells after AHSCT. (A) Mean (± SE) frequency of CD27^brightIgD⁻ plasma cells, CD27⁺IgD⁻ switched memory, CD27⁺IgD⁺ nonswitched memory, CD27⁻IgD⁺ naive, and CD27⁻IgD⁻ double-negative B cells immunophenotyped by flow cytometry at baseline (0 months, pretransplant) and following time points. (B) Quantification of the B-cell subpopulations absolute values. *P < .05 comparing posttransplant values to baseline (Wilcoxon’s). (C) Correlation between naive B-cells count and sjKREC values (Spearman’s). (D) Mean (± SE) frequency of CD38⁻IgD⁺ Bm1, CD38^lowIgD⁺ Bm2, CD38^highIgD⁺ Bm2′, CD38^highIgD⁻ Bm3+4, CD38^lowIgD⁻ early Bm5, and CD38⁻IgD⁻ late Bm5 B cells immunophenotyped by flow cytometry at baseline and following time points. (E) Quantification of the B-cell subpopulations absolute values. *P < .05; **P < .01 comparing posttransplant values to baseline (Wilcoxon’s). (F) Correlation between Bm2 B-cells count and sjKREC values (Spearman’s). N = 18 transplanted patients at baseline, n = 14 at 6 and 12 months, n = 9 at 18 months, n = 12 at 24 months, and n = 7 at >24 months.