Effects of anti-FXI IgG 14E11 in the murine myocardial ischemia-reperfusion model. (A) Representative sections of mouse hearts from animals treated during ischemia with vehicle (top) or 14E11 (bottom), followed by 2-hour reperfusion. The images on the left show the AAR of ischemia as areas devoid of fluorescent microspheres, whereas the TTC-stained images at right show infarcted tissue (paler areas in which the TTC stain is not taken up). (B) AARs for each group were calculated and are presented as percentages of total ventricular volume. (C) Treatment with 14E11 reduced the infarct size (percentage of AAR undergoing infarction) after regional myocardial ischemia-reperfusion. Data are shown as the means ± SEM of infarct size normalized to the AAR (n = 10 mice/group; *P ≤ .0001, 14E11 vs vehicle).