HLH-like manifestation after LCMV infection in different mouse groups. (A) Serum cytokine levels were assayed 8 days after LCMV infection. Levels were lower in the treated groups (J/B6 and J/Munc) compared with nontreated controls. (B) Body weight and temperature were measured every 2 days postinfection; the intergroup difference was significant at euthanasia (D14 postinfection). Body weight is presented as a percentage of the value on D0 (the day of infection). (C) At euthanasia, the WBC and RBC counts were measured. All data are presented as the mean ± standard error of the mean. Sahpiro-Wilk test was used to evaluate the normal distribution of the data. P values were calculated using a Mann-Whitney U test for IL-6 and TNF-α levels (which are not normally distributed) and an unpaired Student t test for all other parameters. *P < .05; **P < .01; ***P < .001; ****P < .0001. Hct, hematocrit.